New FTD HPV High Risk kit now available

 

FTD completes its comprehensive Sexually Transmitted Infections panel by offering a multiplex real-time PCR kit for the detection of human papillomavirus 16, human papillomavirus 18, and a pool of 12 other High Risk human papillomavirus, including an endogenous control.

The human papillomavirus (HPV) is a double-stranded circular DNA virus that can be easily transmitted through sexual contact. HPV infection is one of the most common viral infections of the reproductive tract and is the major risk factor for the development of cervical carcinoma. From over 150 genotypes of HPV being identified, 14 High Risk genotypes are responsible for nearly all cervical cancers, with HPV type 16 and 18 alone accounting for over 70% of cases.
Although over 90% of HPV infections are resolved within 2 years, a small proportion of infections from any of the 14 High Risk HPV genotypes can persist and progress into neoplastic lesions. Cervical cancer screening based on cytology, despite being specific, has a high rate of false negatives and often fails to prevent adenocarcinoma of the cervix.

 

References:
(1) Cuzick, J. et al. (2006) Journal of Cancer, 119(5), pp. 1095-1101
(2) Groves, I.J. et al. (2015) Journal of Pathology, 235, pp. 527-538

 

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