2017 Article - "Neisseria meningitidis nasopharyngeal carriage during the Hajj: A cohort study evaluating the need for ciprofloxacin prophylaxis" (limited access)

Summary: The annual Muslim pilgrimage has the potential of increase risk for acquisition of Neisseria meningitidis. Here, the authors evaluate the Hajj impact on the prevalence of N. meningitidis carriage with the help of culture and PCR in a paired and non-paired cohort of pilgrims. Secondary objectives were to calculate the compliance with recommended vaccination. This is a prospective paired (arriving and departing), non-paired arriving and non-paired departing cohort study with the collection of nasopharyngeal samples at the start and the end of the Hajj. The study included unpaired arriving pilgrims at King Abdul Aziz International Airport (N = 1055), unpaired departing cohort (N = 373), and a paired cohort (N = 628) who were tested on arrival and departure. 

This the largest study of the epidemiology of N. meningitidis among pilgrims. The study showed a significant difference in the carriage between pilgrims from high endemicity and other pilgrims with a predominance of serogroup B. The continued use of ciprofloxacin as prophylactic antibiotics should be reconsidered as well as the consideration to add serogroup B as a required vaccination.

Kit used: FTD Bacterial meningitis
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